Cost-effectiveness of active surveillance versus early surgery for thyroid micropapillary carcinoma based on diagnostic and treatment norms in China
نویسندگان
چکیده
Objectives In this study, we compared the cost-effectiveness comparison of active surveillance (AS) and early surgery (ES) approaches for papillary thyroid microcarcinoma (PTMC) from perspective Chinese healthcare system. Methods We performed a analysis using Markov model PTMC developed to evaluate incremental ratio AS ES. Our reference case was 40-year-old woman diagnosed with unifocal (<10 mm) PTMC. Relevant data were extracted after an extensive literature review, cost incurred in each state determined China Medicare on payments ES AS. The willingness-to-pay threshold set at ¥242,928/quality-adjusted life-year (QALY) gained. Sensitivity analyses account any uncertainty model’s variables. Additional subgroup determine whether cost-effective when different initial monitoring ages used. Results exhibited effectiveness 5.2 QALYs, whereas showed 25.8 QALYs. Furthermore, versus ¥1,009/QALY. findings all sensitivity robust. Compared ES, found be strategy 20 60 years, ¥3,431/QALY −¥1,316/QALY respectively. more patients aged than 60. Conclusions With respect norms system, over lifetime it even different. addition, if is incorporated into management plan earliest possible stage, predicted savings ¥10 × 10 8 /year could enabled every 50,000 cases PTMC, which indicates good economic return future programs. identification such nuances can help physicians best most individualized long-term low-risk
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2023
ISSN: ['1664-2392']
DOI: https://doi.org/10.3389/fendo.2023.1166433